427284 Recognition of L-Amino Acid at Liposome Membrane Surface and Its Application for Homochiral Polymerization

Thursday, November 12, 2015: 5:03 PM
251A (Salt Palace Convention Center)
Takaaki Ishigami1, Yoshinori Kaneko2, Keishi Suga1, Yukihiro Okamoto1 and Hiroshi Umakoshi1, (1)Div. of Chem. Eng., Grad. Sch. of Eng. Sci., Osaka University, Toyonaka, Japan, (2)Div. of Chem. Eng., Grad. Sch. of Eng. Sci, Osaka University, Toyonaka, Japan

We report the enantioselective adsorption of an L-amino acid on an L-form liposome and amino acid polymerization on the liposome. L-form liposomes are involved in the enantioselective binding and concentration of adsorbed L-amino acids, and protect activated intermediates from hydrolysis. The use of L-form liposomes therefore enables homochiral polymerization and more efficient polymerization of L-amino acids than of D-amino acids. Our developed method can therefore be used for the synthesis of homochiral biopolymers from racemic monomers and could be helpful in understanding prebiotic biopolymer formation.

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See more of this Session: Biomolecules at Biomaterial Interfaces
See more of this Group/Topical: Materials Engineering and Sciences Division