415050 Prediction of Feasible Operating Region for an Integrated Set of Unit Operations

Monday, November 9, 2015: 2:12 PM
Ballroom B (Salt Palace Convention Center)
Carla Luciani1, Salvador García-Muñoz1, Kevin Seibert1, Thomas Wilson2 and Eric Crick2, (1)Small Molecule Design and Development, Eli Lilly & Co., Indianapolis, IN, (2)Small Molecule Design and Development, Eli Lilly & Co, Indianapolis

Title: Prediction of Feasible Operating Region for an Integrated Set of Unit Operations

Authors: Carla Luciani, Salvador Garcia, Kevin Seibert, Thomas Wilson, Eric Crick

In this work, the prediction of feasible operating regions for a set of integrated unit operations will be discussed. Particularly, three unit operations will be investigated: a Suzuki coupling reaction, a liquid-liquid extraction, and metal removal in a series of continuous adsorption columns. The prediction of the feasible operating region is aided by a mechanistic model built. 



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See more of this Session: Application of Quality by Design in Drug Substance Process Development
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