361 Applications of Continuous Processing in the Manufacture of Pharmaceuticals: Drug Substance II

Tuesday, November 18, 2014: 3:15 PM
203 (Hilton Atlanta)
Description:
Enabled by new technology, continuous processing offers new methods of increasing safety, selectivity, and yield for chemical and biochemical processes. Improved control over process streams enables operation at extreme conditions with reduced sensitivity to scale-up effects. This session will focus on applications of continuous processing to the production of drug substances or their intermediates.

Sponsor:
Pharmaceutical Discovery, Development and Manufacturing Forum

Chair:
Subramanya Nayak
Email: subramanya.nayak@abbvie.com

Co-Chair:
Jacob Albrecht
Email: jacob.albrecht@bms.com

- indicates paper has an Extended Abstract file available on CD.


3:15 PM
(361a) Optimal Startup of a Continuous Pharmaceutical Process
Ali M. Sahlodin and Paul Barton

3:40 PM
(361b) Operation Strategy Development for Grignard Reaction in a Continuous Stirred Tank Reactor
Sze Wing Wong, Shujauddin M. Changi, Richard Shields, Willis V. Bell III and Bernard M. McGarvey
File available
4:05 PM
(361c) A Computational Analysis of a Combined Cooling Anti-Solvent Continuous Crystallization Cascade: A Paracetamol/Methanol/Water Case Study
K. Hutton and P.J. Frawley

4:30 PM
(361d) Obtaining Pure Enantiomers and Co-Crystals Using Continuous Preferential Crystallization: A Process Development Investigation Using Population Balance Models
Thomas Vetter, Christopher L. Burcham and Michael F. Doherty

4:55 PM
(361e) Process Modeling, Simulation and Optimization for Continuous Pharmaceutical Manufacturing (CPM) of Ibuprofen
Hikaru G. Jollifffe and Dimitrios I. Gerogiorgis

5:20 PM
(361f) Continuous Purification of Active Pharmaceutical Ingredients Using Multistage Organic Solvent Nanofiltration Membrane Cascade
Ludmila Peeva, Joao da Silva Burgal and Andrew G. Livingston
See more of this Group/Topical: Pharmaceutical Discovery, Development and Manufacturing Forum
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