282 Quantitative Approaches to Disease Mechanisms & Therapies

Tuesday, November 18, 2014: 8:30 AM
201 (Hilton Atlanta)
Description:
This session highlights applying conventional – e.g., reaction and transport phenomena – and emerging – e.g., dynamical systems and statistical mechanics – concepts from (bio)chemical engineering to aid in understanding disease mechanisms and designing therapies. Submissions that integrate experimental work with simulation and that demonstrate a clear connection between engineering fundamentals and disease pathophysiology are particularly encouraged.

Sponsor:
Engineering Fundamentals in Life Science
Co-Sponsor(s):
Systems and Process Control (10B), Applied Mathematics and Numerical Analysis (10D)

Co-chairs:
Matthew J. Lazzara
Email: mlazzara@seas.upenn.edu

Stacey Finley
Email: sfinley@usc.edu


8:30 AM
(282a) 13C Metabolic Flux Analysis of Metabolic Reprogramming Induced By AKT Signaling in Cancer Cells
Casey S. Duckwall and Jamey D. Young

8:48 AM
(282b) A Generalizable Optimization Algorithm for Clinically-Relevant Patient-Specific Cancer Chemotherapy Scheduling
Thang Ho, Carl Laird, Yankai Cao and Robert S. Parker

9:06 AM
(282c) Design of a Digital Controller for a Fully Implantable Closed-Loop Artificial Pancreas
Lauren M. Huyett, Dale E. Seborg and Francis J. Doyle III

9:24 AM
(282d) Elucidating Mechanisms of Liver Metastasis: An All-Human Microphysiological Model to Investigate Disease Progression & Therapies
Carissa L. Young, Sarah E. Wheeler, Amanda M. Clark, Donna B Stolz, Alan Wells, Linda G. Griffith and Douglas Lauffenburger

9:42 AM
(282e) Tumor Vascular Status Regulates Molecular Dissemination into Regional and Systemic Tissues
Nathan A. Rohner and Susan N. Thomas

10:00 AM
(282f) Impact of Necrotizing Enterocolitis on the Barrier Properties of Intestinal Mucus
Taylor Carlson, Hasan M. Yildiz, Erika Claud and Rebecca L. Carrier

10:18 AM
(282g) Human Metabolic Response to Systemic Inflammation: Concordance Between the Experimental Endotoxemia and Clinical Cases
Kubra Kamisoglu, Steve E. Calvano, Susette M. Coyle, Siobhan A. Corbett and Ioannis P. Androulakis

10:36 AM
(282h) The Effects of Fluid Shear Stress on Cancer Stem Cells
Ursula L. Triantafillu, Ria C. Domier, David A. Dozier and Yonghyun (John) Kim
See more of this Group/Topical: Food, Pharmaceutical & Bioengineering Division
<< Previous Session | Next Session >>