205 Nucleic Acid Delivery

Monday, November 17, 2014: 3:15 PM
201 (Hilton Atlanta)
Description:
Successful translation of nucleic acid therapies into the clinic hinges on efficient delivery into the desired sub-cellular compartment. Achieving this goal of intracellular delivery requires understanding and overcoming a multitude of biological barriers. As such, this session seeks to explore topics associated with (but not limited to) fundamental studies on key extracellular/intracellular pathways, trafficking of delivery vehicles, and design and development of novel carriers, in order to overcome biological barriers resulting in high efficacies of nucleic acid treatments in vitro and in vivo

Sponsor:
Engineering Fundamentals in Life Science
Co-Sponsor(s):
Biomedical Applications of Chemical Engineering (T7)

Chair:
Christopher A. Alabi
Email: caa238@cornell.edu

Co-Chair:
Kaushal Rege
Email: krege@asu.edu


3:15 PM
(205a) Inhibition of Intracellular Histone Deacetylate (HDAC) Enzymes for Enhancement of Transient Transgene Expression
Jacob Elmer, Matthew Christensen, Sutapa Barua, Jennifer Lehrman and Kaushal Rege

3:33 PM
(205b) Dual-Targeted Heteromultivalent Liposomal Gene Delivery for Cancer Therapy
Rachel M. Levine and Efrosini Kokkoli

3:51 PM
(205c) Investigating the Molecular Factors That Facilitate Nonviral Gene Delivery through Targeted Cellular Pathway Priming Studies and Telecommunications Modeling of DNA Transfer
Timothy M. Martin, Abby M. Kelly, Jared Beyersdorf, Sarah A. Plautz and Angela K. Pannier

4:09 PM
(205d) A Lipid Nanoparticle siRNA Delivery System for B Cell Lymphoma
Christopher Knapp and Kathryn A. Whitehead

4:27 PM
(205e) pH-Responsive Chitosan Nanoparticles As a Gene Therapy-Based Nanoantibiotic
Julius A, Edson, Sukumar Pal, Shirley Wu, Bianca Lee, Luiz de la Maza and Young Jik Kwon

4:45 PM
(205f) Improvements in Nucleic Acid Delivery Using VSV-G Vesicles
Mathias Mangion, Igor Slivac, Alexandre Audy, Jacques-P Tremblay, Chantale Maltais, Alain Garnier and Bruno Gaillet

5:03 PM
(205g) RAFT Synthesis of pH Responsive Diblock Copolymers for Gene Delivery
Annie McClellan

5:21 PM
(205h) Combinatorial Synthesis of Lipid-Conjugated Aminoglycoside-Derived Polymers for Transgene Delivery
Bhavani Miryala, Zhuo Zhen, Thrimoorthy Potta, Curt Breneman and Kaushal Rege
See more of this Group/Topical: Food, Pharmaceutical & Bioengineering Division
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