105 Applications of Continuous Processing in the Manufacture of Pharmaceuticals: Drug Substance I

Monday, November 17, 2014: 12:30 PM
202 (Hilton Atlanta)
Description:
Enabled by new technology, continuous processing offers new methods of increasing safety, selectivity, and yield for chemical and biochemical processes. Improved control over process streams enables operation at extreme conditions with reduced sensitivity to scale-up effects. This session will focus on applications of continuous processing to the production of drug substances or their intermediates.

Sponsor:
Pharmaceutical Discovery, Development and Manufacturing Forum
Co-Sponsor(s):
Pharmaceuticals (15B)

Chair:
Jacob Albrecht
Email: jacob.albrecht@bms.com

Co-Chair:
Subramanya Nayak
Email: subramanya.nayak@abbvie.com


12:30 PM
(105a) Development of a Multistep Continuous Process and Manufacturing for a Key Pharmaceutical Intermediate of Dapagliflozin
Chenchi Wang, Prashant Deshpande, Junying Fan and Laurent Lehmann

12:55 PM
(105b) Process Intensification Using a Continuous Packed Bed Reactor for Enzymatic Hydrolysis
Dimitri Skliar, Thomas L. LaPorte, Sara Chuang, Amarjit Singh, Nicolas Cuniere and Animesh Goswami

1:20 PM
(105c) Organic Solvent Nanofiltration in Continuous Catalytic Reactions
Ludmila Peeva, Joao da Silva Burgal and Andrew G. Livingston

1:45 PM
(105d) Development of Continuous Antisolvent Nucleation Processes to Achieve Better Control over Crystalline Particle Attributes
Anna Jawor-Baczynska, Ulrich Schacht, Naomi Briggs, Alastair J. Florence and Jan Sefcik

2:10 PM
(105e) Avoiding Microreactor Clogging By Inorganic Solid Formation in Continuous Chemical Synthesis of Pharmaceutical Compounds
Gaurav Giri and Klavs F. Jensen

2:35 PM
(105f) Controlled Accumulation of Inorganic Salts in Microreactors for Palladium-Catalyzed Amination
Yizheng Chen and Ryan L. Hartman
See more of this Group/Topical: Pharmaceutical Discovery, Development and Manufacturing Forum
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