631 Fundamentals of Protein Folding in Diseases

Thursday, November 20, 2014: 8:30 AM
205 (Hilton Atlanta)
This session seeks submissions focused on experimental and theoretical characterization and prediction of the thermodynamics and mechanism(s) of protein folding as well as the role that aggregates play in disease pathogenesis. Areas of interest include, but are not limited to, the dynamics and mechanisms of protein aggregation, the formation of off-pathway aggregates, the characterization of aggregate size and structure, the therapeutic inhibition of aggregation, and the interaction of aggregates with target cells.

Engineering Fundamentals in Life Science (15D)

Melissa A. Moss
Email: mossme@cec.sc.edu

Nikhil U. Nair
Email: nikhil.nair@tufts.edu

- indicates paper has an Extended Abstract file available on CD.

8:30 AM
(631a) A Cyclic Peptide Mimic of the Beta-Amyloid Binding Domain on Transthyretin
Patricia Y. Cho, Regina M. Murphy, Gururaj Joshi and Jeffrey Johnson

8:48 AM
(631b) Hofmeister Effects on Prion Strain Generation and Cross-Species Prion Transmission
Aditi Sharma, Sven H. Behrens, Yury Chernoff and Andreas S. Bommarius

9:24 AM
(631d) Solid State NMR Evidence for Antiparallel β-Sheet Structure within Toxic Oligomers of the Alzheimer's β-Amyloid Peptide
Danting Huang, Maxwell Zimmerman, Patricia K. Martin, A. Jeremy Nix, Terrone L. Rosenberry and Anant K. Paravastu

9:42 AM
File available
10:06 AM
(631f) Formation of Amyloid Fibrils By Protein Fragments
Daniel Forciniti, Jose Morales and Jessica Randall
See more of this Group/Topical: Food, Pharmaceutical & Bioengineering Division