631 Fundamentals of Protein Folding in Diseases

Thursday, November 20, 2014: 8:30 AM
205 (Hilton Atlanta)
Description:
This session seeks submissions focused on experimental and theoretical characterization and prediction of the thermodynamics and mechanism(s) of protein folding as well as the role that aggregates play in disease pathogenesis. Areas of interest include, but are not limited to, the dynamics and mechanisms of protein aggregation, the formation of off-pathway aggregates, the characterization of aggregate size and structure, the therapeutic inhibition of aggregation, and the interaction of aggregates with target cells.

Sponsor:
Bioengineering
Co-Sponsor(s):
Engineering Fundamentals in Life Science (15D)

Chair:
Melissa A. Moss
Email: mossme@cec.sc.edu

Co-Chair:
Nikhil U. Nair
Email: nikhil.nair@tufts.edu

- indicates paper has an Extended Abstract file available on CD.


8:30 AM
(631a) A Cyclic Peptide Mimic of the Beta-Amyloid Binding Domain on Transthyretin
Patricia Y. Cho, Regina M. Murphy, Gururaj Joshi and Jeffrey Johnson

8:48 AM
(631b) Hofmeister Effects on Prion Strain Generation and Cross-Species Prion Transmission
Aditi Sharma, Sven H. Behrens, Yury Chernoff and Andreas S. Bommarius

9:06 AM
(631c) The Natural Stilbenoid Resveratrol and Its Derivatives' Inhibitory Capability Toward Alzheimer's Disease Associated Amyloid-β Protein Aggregation
Yiying Wang and Melissa A. Moss

9:24 AM
(631d) Solid State NMR Evidence for Antiparallel β-Sheet Structure within Toxic Oligomers of the Alzheimer's β-Amyloid Peptide
Danting Huang, Maxwell Zimmerman, Patricia K. Martin, A. Jeremy Nix, Terrone L. Rosenberry and Anant K. Paravastu

9:42 AM
Break

9:48 AM
(631e) Tannic Acid Inhibits Amyloid Beta Aggregation with Specificity for an Oligomer Species
Nicholas van der Munnik and Melissa A. Moss
File available
10:06 AM
(631f) Formation of Amyloid Fibrils By Protein Fragments
Daniel Forciniti, Jose Morales and Jessica Randall

10:24 AM
(631g) A Causative Link Between Abeta Binding and Its Clearance and Toxicity for Alzheimer's Disease
Brian Murray, Payel Das and Georges Belfort

10:42 AM
(631h) Characterization of Prion Protein Self-Interactions By Yeast Surface Display and Next-Generation Sequencing
Kyle M. Doolan and David W. Colby
See more of this Group/Topical: Food, Pharmaceutical & Bioengineering Division
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