395911 Incorporation of Plant Architectures within Microfluidic Devices

Monday, November 17, 2014
Galleria Exhibit Hall (Hilton Atlanta)
Kim Le1, Ning Ge2, Brad Berron3 and Christine Trinkle2, (1)Bioengineering, Rice University, Houston, TX, (2)Mechanical Engineering, University of Kentucky, Lexington, KY, (3)Dept of Chemical and Materials Engineering, University of Kentucky, Lexington, KY

One of the most significant challenges in microfluidics and tissue engineering is the efficient delivery of fluids and solutes throughout the system. Many natural organisms have already developed a solution to this problem, in the form of active or passive circulatory systems. This research focuses on developing a procedure for creating a PDMS microfluidic device with a pre-existing system: venation in plant leaves taken directly from nature. Such a device has great potential as synthetic vascular scaffold for tissue engineering purposes, as the geometry allows effective transport, but is still relatively planar, making it more adaptable to microfabrication processes. In this work, the surface topography and vein cross-section from both the leaves and molds were characterized, along with the fluid flow within the channels. An effective method of isolating a leaf’s vasculature was additionally found and evaluated. Although there are some limitations in alignment, resulting in an altered cross-sectional morphology and fluid flow, the individual portions of the mold effectively capture the dimensions and patterning of the vasculature.

Extended Abstract: File Not Uploaded
See more of this Session: Undergraduate Student Poster Session: Education & General Papers
See more of this Group/Topical: Student Poster Sessions