394826 Polymer Film Coatings on Erythrocytes for Extended Release of Chemotherapy

Monday, November 17, 2014
Galleria Exhibit Hall (Hilton Atlanta)
Katherine Donaldson1, Jacob Lilly2, Hainsworth Shin3 and Brad Berron2, (1)Chemical and Biological Engineering, University of Alabama, Tuscaloosa, AL, (2)Chemical and Materials Engineering, University of Kentucky, Lexington, KY, (3)Biomedical Engineering, University of Kentucky, Lexington, KY

This is an investigation of a novel method of using erythrocytes as carriers for the delivery of chemotherapeutics. Intravenously administered nanoparticle therapies are not optimally effective because nanoparticles have short circulation lives before being cleared from the bloodstream. By trapping chemotherapeutic nanoparticles in films coatings, we seek to prolong the release of the drug. A means of extending drug release and circulation time would alter the pharmacokinetics of the drug, potentially improving the efficacy of treatment with less frequent dose administration

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