390673 Synchronization of Cellular Skeleton Determines the Nature of Motions of Cancerous Vs. Non-Cancerous Cells

Tuesday, November 18, 2014: 9:06 AM
214 (Hilton Atlanta)
Fateme Sadat Emami1, Amir Vahid1, Bartosz A. Grzybowski2 and Kristiana Kandere-Grzybowska3, (1)Non-Equilibrium Energy Research Ctr, Chemical and Biological Engineering Dept, Northwestern University, Evanston, IL, (2)Chemical Engineering, Northwestern University, Evanston, IL, (3)Chemical and Biomolecular Engineering, Northwestern University, Evanston, IL

Protrusions/retractions arise from forces exerted by cell cytoskeleton components to the front and back of the cells. Here, we study if overall motility strategy (diffusive versus LÚvy walks) can be emerged from the front/back dynamics and weather synchronization between the two affect the overall cell movement. We have shown that a series of persistent non-Markovian infinitesimal moves could result in a power law distribution of the persistence length characterizing a LÚvy walk distribution. To consider the protrusions/retractions of the cell with a primitive model represented by two connected moving points. These front and back compartment of the model were allowed to move with or without synchronization considering limitation on the overall cell size. The statistics of this unidirectional excursions were then collected to characterizing probability distributions type of motion. The model showed that the synchronization strategy affects overall cell motility pattern.

Extended Abstract: File Not Uploaded