390550 Orthogonal Engineering of Block Copolymers: Tools, Techniques and Applications

Sunday, November 16, 2014
Galleria Exhibit Hall (Hilton Atlanta)
Mohiuddin Quadir1, Stephen Morton2, Lawrence Mensah1, Jason Deng1, Kevin Shopsowitz1, Ryan P. Murphy3, Thomas H. Epps III3 and Paula T. Hammond2, (1)Koch Institute for Integrated Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, (2)Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, (3)Chemical and Biomolecular Engineering, University of Delaware, Newark, DE

Application-directed chemical modification of synthetic and natural polymers can generate bio-functional analogues with diverse topology. Synthetic block copolymers with ordered structural hierarchy are powerful fabrication tools for creating self-assembled systems with applied functionality. Robust and sterically stabilized nanostructures, such as conjugates, micelles and vesicles can be engineered from these synthetic block copolymers to design effective and targeted drug delivery vehicles. However, limited availability of functional monomers, synthetic complexity of polymerization, and lack of orthogonality during post-polymerization processes require efficient and modular synthesis of the polymer backbone. Intelligent application of functional-group specific chemistry, multivalent amplification of linear polymers using dendritic building blocks, and hybridization of natural polymers with synthetic macromolecules can open up a wide range of possibilities for the development of bio-inspired materials with desired form and function.

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