386924 Predictive Screening of Column Pair Combinations for Two-Dimensional Liquid Chromatography
Predictive Screening of Column Pair Combinations for Two-dimensional Liquid Chromatography
Rebecca K. Lindsey,1 Dwight R. Stoll,2 Peter W. Carr,1 and J. Ilja Siepmann1,3†
1Department of Chemistry and Chemical Theory Center, University of Minnesota, Minneapolis, MN 55455-0431
2Department of Chemistry Gustavus Adolphus College, Saint Peter, Minnesota 56082
3Department of Chemical Engineering and Materials Science University of Minnesota, Minneapolis, MN 55455-0431
Two-dimensional liquid chromatography (2DLC) is a powerful separation technique that employs a second column to further separate fractions taken from the first column; when utilized in an on-line fashion, 2DLC can result in much higher total peak capacities than are achievable with a single column. This computational work addresses the significant challenge of selecting an optimal column pair from the N2 possible combinations (order matters in the on-line approach) by presenting a predictive screening method for column pair selection, and provides insight into the defining characteristics of a good column pair.
†Corresponding Author. E-mail: email@example.com