386924 Predictive Screening of Column Pair Combinations for Two-Dimensional Liquid Chromatography

Thursday, November 20, 2014: 9:15 AM
310 (Hilton Atlanta)
Rebecca K. Lindsey1, Dwight R. Stoll2, Peter W. Carr3 and J. Ilja Siepmann1, (1)Department of Chemistry and Chemical Theory Center, University of Minnesota, Minneapolis, MN, (2)Chemistry, Gustavus Adolphus College, Saint Peter, MN, (3)Chemistry, University of Minnesota, Minneapolis, MN

Predictive Screening of Column Pair Combinations for Two-dimensional Liquid Chromatography

Rebecca K. Lindsey,1 Dwight R. Stoll,2 Peter W. Carr,1 and J. Ilja Siepmann1,3†

1Department of Chemistry and Chemical Theory Center, University of Minnesota, Minneapolis, MN 55455-0431
2Department of Chemistry Gustavus Adolphus College, Saint Peter, Minnesota 56082
3Department of Chemical Engineering and Materials Science University of Minnesota, Minneapolis, MN 55455-0431

Two-dimensional liquid chromatography (2DLC) is a powerful separation technique that employs a second column to further separate fractions taken from the first column; when utilized in an on-line fashion, 2DLC can result in much higher total peak capacities than are achievable with a single column. This computational work addresses the significant challenge of selecting an optimal column pair from the N2 possible combinations (order matters in the on-line approach) by presenting a predictive screening method for column pair selection, and provides insight into the defining characteristics of a good column pair.

Corresponding Author. E-mail: siepmann@umn.edu


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