380870 Experimental Study of Feedcol Strategy on Simulated Moving Bed Chromatography with Mal-Functional Column Configuration

Tuesday, November 18, 2014
Galleria Exhibit Hall (Hilton Atlanta)
Ji-Yeon Song and Chang-Ha Lee, Chemical and Biomolecular Engineering, Yonsei University, Seoul, South Korea

Simulated Moving Bed (SMB) Chromatography has been considered as important separation process due to its effective separation process. Therefore, it has been widely used in various industries including petrochemicals, fine chemicals, pharmaceuticals and biotechnology etc. In the previous study, the FeedCol strategy was introduced for improving performance parameters by applying one short chromatographic column to the SMB process. The experimental study of the FeedCol strategy was performed in the SMB with partially mal-functional column configuration (two of eight columns are malfunctioning) and two sets of the FeedCol experiments were performed with various injection times at the fixed injection length of 50%. The experimental performance of FeedCol strategy was compared with the experimental results of conventional SMB process (2-2-2-2 configuration) with the same columns. In addition, the experimental results of FeedCol strategy and conventional SMB were compared with the simulation results of conventional SMB with normal columns. It was proved experimentally that the FeedCol strategy showed better performance than the conventional SMB at the same condition and even the conventional SMB with normal column. As a result, the FeedCol operation was proved as one of strong operational strategies to improve the SMB performance.

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