377231 Centrifugal Separation of Disk Centrifuge in Downstream Processing
Disk centrifuges have been widely used for downstream harvesting of yeast, mammalian and microbial cells. Heretofore, the operation of the centrifuges is largely based on ad-hoc trial-and-error experiences.
A model of separating cells using a disk centrifuge is presented. The model is validated against experiments on a pilot-scale centrifuge. An interesting example is used to illustrate how the model can be used to predict performance of inclusion-body separation.
 Wallace Woon-Fong Leung, Centrifugal Separations in Biotechnology, Academic Press, UK, 2007.
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