374276 A Multi-Targeted Drug Delivery Vehicles for Dual Chemo- and Photothermal HER2+ Breast Cancer Therapy

Wednesday, November 19, 2014
Galleria Exhibit Hall (Hilton Atlanta)
Yonghyeon Yang and Jin-Oh You, Engineering Chemistry, Chungbuk National University, Cheongju, South Korea

Eradication of breast cancer cells via targeted, triggered release, or thermal ablation methods remains a challenge in the clinic. One dimensional approaches suffer from reoccurence, chemoresistance, and/or toxicity, which warrants the design of a novel, multi-targeted therapeutic with an improved therapeutic index. Here, we synthesized a drug delivery vehicle encapsulating doxorubicin (Dox) within a pH-sensitive matrix, embedded gold (Au) nanoparticles within the interior, and decorated the surface with an antibody for human epidermal growth factor receptor-2 (anti-HER2, Herceptin®). The pH-responsive matrix entrapped Dox, achieving greater than 70% encapsulation efficiency. Our multi-targeted nanocarrier enhanced specific binding and tumoricidal efficacy in a HER2 overexpressing cell line, SK-BR-3, relative to MCF-7 cells. We demonstrated that multiple modes of targeting were complementary and have potential for use as a cancer therapy.

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See more of this Session: Poster Session: Bioengineering
See more of this Group/Topical: Food, Pharmaceutical & Bioengineering Division