367456 Enhanced Electrohydrodynamic Collapse of DNA Due to Dilute Polymers
367456 Enhanced Electrohydrodynamic Collapse of DNA Due to Dilute Polymers
Tuesday, November 18, 2014: 8:45 AM
Marquis Ballroom A (Marriott Marquis Atlanta)
We experimentally demonstrate that addition of small, charge-neutral polymers to a buffer solution can promote compression of dilute solutions of single electrophoresing DNA. This phenomenon contrasts with the observed extension of DNA during capillary electrophoresis in dilute solutions of high molecular weight polymers. We propose these discrepancies in micron-scale DNA configurations arise from different nano-scale DNA-polymer collision events, controlled by solute polymer properties. We build upon theories previously proposed for intermolecular DNA aggregation in polymer-free solutions to develop scaling theories that describe trends seen in our data for intramolecular DNA compaction in dilute polymer solutions.
See more of this Session: Microfluidic and Microscale Flows I: Separations and Electrokinetics
See more of this Group/Topical: Engineering Sciences and Fundamentals
See more of this Group/Topical: Engineering Sciences and Fundamentals