230 Advances in Predictive Scale Down Capabilities

Tuesday, November 5, 2013: 8:30 AM
Plaza B (Hilton)
Description:
We invite presentations on projects where small scale results were translated to or used to represent pilot or manufacturing scale (scale-up) or vice versa (scale-down). Of most interest are projects i) with a large difference in scale (e.g. volume scale factor of 1000 or more), or where the laboratory scale was smaller than standard practice and ii) where the basis of successful scaling is understood and will be presented (e.g. in the form of dimensionless groups, or other models). We also welcome presentations where lab scale equipment was characterized experimentally (e.g. with respect to mixing, heat transfer) in order to then design appropriate experiments for successful scale-up or scale-down.

Sponsor:
Pharmaceutical Discovery, Development and Manufacturing Forum
Co-Sponsor(s):
Pilot Plants (12b)

Chair:
Joe Hannon
Email: joe.hannon@scale-up.com

Co-Chair:
Arun V. Giridhar
Email: agiridha@ecn.purdue.edu

- indicates paper has an Extended Abstract file available on CD.


9:45 AM
(230d) Modeling of the Secondary Drying and the Fate of Organic Solvents for Spray Dried Dispersion (SDD) Product
Daniel Hsieh, Hongfei Yue, Sarah Nicholson, Daniel Roberts, Richard Schild, John Gamble and Mark Lindrud

10:35 AM
(230f) Bilayer Tablet Compaction: Translation From a Single Stage Compaction Simulator to a Rotary Press
Jasmine M. Rowe, Keirnan LaMarche, Brian Carroll, Preetanshu Pandey, Ganeshkumar A. Subramanian and Faranak Nikfar