298 Crystallization Process Development II

Tuesday, November 5, 2013: 12:30 PM
Union Square 20 (Hilton)
Crystallization is an industrially important unit operation for isolation and purification of a wide range of chemical products, including pharmaceuticals and fine chemicals. Developing a crystallization process can be challenging, often complicated by multiple components and requirements that the solids are consistently isolated in the desired polymorphic forms, compounds, adducts, or solvates. Control of particle size distribution may be needed to avoid difficult filtrations or high impurity content. This session welcomes contributions related to theoretical as well as practical approaches to crystallization process development, including techniques and tools that can lead to more efficient development of robust crystallization processes. Case studies and examples of how commercial crystallization processes are developed, and papers which describe the design and operation of batch or continuous crystallization processes are particularly encouraged.

Process Research and Innovation
Crystallization and Evaporation (02B), Solids Flow, Handling and Processing (03C)

Christianto Wibowo
Email: cwibowo@cwbtech.com

James C. Marek
Email: james.marek@abbvie.com

Bruce D. Hook
Email: BDHook@dow.com

- indicates paper has an Extended Abstract file available on CD.

12:30 PM
File available
12:52 PM
(298b) Generic Modelling Framework for Design and Analysis of Crystallization Operations
Kresten Troelstrup Meisler, Noor Asma Fazli Abdul Samad, Krist V. Gernaey and Rafiqul Gani

1:14 PM

1:36 PM
(298d) Stable Configurations in the Horizontal Ribbon Growth Process
German A. Oliveros, B. Erik Ydstie and Seetharaman Sridhar

1:58 PM
(298e) Using ATR-FTIR to Track the Crystallization of Multiple Solutes
Daniel Griffin, Martha Grover, Yoshiaki Kawajiri and Ronald W. Rousseau
See more of this Group/Topical: Process Development Division