724 Cell Culture III: Metabolic Flux Analysis and Modeling

Thursday, November 7, 2013: 3:15 PM
Golden Gate 2 (Hilton)
Description:
This session intends to cover the state-of-the-art in mammalian, plant, algal and insect cell culture toward the production of biofuels, therapeutics and high-value secondary metabolites. This session will focus on phenotype characterization using metabolic flux analysis and metabolomics, and the development of mathematical models towards prediction and control of cell culture behavior on small and large scales.

Sponsor:
Bioengineering

Chair:
Vijayakumar Janakiraman
Email: vijay.janakiraman@biogenidec.com

Co-Chair:
Maciek R. Antoniewicz
Email: mranton@udel.edu


3:15 PM
(724a) Redirection of Glycolytic Metabolism By Overexpression of Bcl-2Δ in CHO Cells
Neil Templeton, Abasha Lewis, Kevin Smith, Haimanti Dorai, Steven Lang, Michael J. Betenbaugh and Jamey D. Young

3:33 PM
(724b) Applying Topological Metabolic Analysis to Industrially Relevant CHO Cell Cultures
Susan T. Sharfstein, Xin Shen, John Mitchell, Eugene Schaefer, Nicole Migliore and Krista Tomlin-Verni

3:51 PM
(724c) Metabolomics and Network Analysis for Sensitive Physiological Monitoring in Industrial Cell Culture Engineering
Spyros Vernardis, Chetan T. Goudar and Maria Klapa

4:09 PM
(724d) Investigation of pH-Induced Metabolic Switch By Flux Balance Analysis and Gene Expression Analysis
Marija Sarenac, Heeju Noh, Massimo Morbidelli and Miroslav Soos

4:27 PM
(724e) Lactate Metabolism in Cell Culture Processes: Model Prediction of the Trajectory to Lactate Consumption
Andrew Yongky, Che-Chi Shu, Bhanu Chandra Mulukutla, Simon Grimm and Wei-Shou Hu

4:45 PM
(724f) Using Metabolic Modeling to Examine Differences in the Metabolism of Chlorella Protothecoides Grown On Glucose Or Glycerol for the Production of Lipids for Biodiesel
John A. Morgan and John O'Grady

5:03 PM
(724g) Isotope-Assisted Metabolic Flux Analysis Reveals Metabolic Landscape Alterations in Poplar Induced By Carbon-Nitrogen Interactions
Xiaofeng Zhang, Shilpa Nargund, Ashish Misra, Gary D. Coleman and Ganesh Sriram

5:21 PM
(724h) Analysis of Central Metabolic Reaction Rates Via Non-Stationary 13C Isotope Study Combined With Kinetic Model in Yeast
Joon Young Jung, Tae Yeon Kim, Dae-Kyun Im and Min-Kyu Oh
See more of this Group/Topical: Food, Pharmaceutical & Bioengineering Division
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