349268 Synthesis and Characterization of Multiblock Copolymers for Vaccine Applications
Synthesis and Characterization of Multiblock Copolymers for Vaccine Applications
Jill Schoborg, Xunpei Liu and Surya Mallapragada
Block copolymers have shown great potential for drug and gene delivery. For this study, a pentablock copolymer based on polyacrylic acid (PAA) and Pluronic F127 was synthesized by atom transfer radical polymerization because of its ability to self-assemble into a thermoresponsive and pH responsive gel, which is beneficial because it can respond to the body’s environment and form a gel at body temperature when injected. These polymers were mixed with PEG diacrylate and a photoinitiator to form photocrosslinked and interpenetrating networks. Parameters for making a gel, such as concentration of polymer and mixing time, were optimized. An increase in concentration and an increase in mixing time yielded a more rigid gel. These gels are being explored for the release of antigens to enable effective vaccine delivery for veterinary applications.
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