348757 Bionano Enzyme Conjugates with Bacterial Decontamination Capabilities

Monday, November 4, 2013
Grand Ballroom B (Hilton)
Andrew Maloney, Chemical Engineering, West Virginia University, Morgantown, WV and Cerasela Zoica Dinu, Department of Chemical Engineering, West Virginia University, Morgantown, WV

Outbreak of severe infections due to unsuccessful decontamination of surfaces could affect both civilians and infrastructures leading to unfavorable socio-economic impacts.  The development of the next generation of decontaminants will need to account for reduction of the logistical burdens associated with infection prevention through use of green technologies.   

 In this work, we seek to create environmentally-friendly, self-sufficient, self-cleaning, enzymatic decontamination bionano conjugates that could be incorporated into fabrics and paints to reduce the operational burdens associated with usage of harsh decontamination agents to prevent infectious outbreaks.   Our technology uses two enzymes, namely glucose oxidase and chloroperoxidase, attached to a nanosupport to generate a potent decontaminant, hypochlorus acid (HOCl). The mechanisms of HOCl generation as well as the conditions that ensure enzyme immobilization, activity and stability at the nanosupports, have been investigated to determine the optimum circumstances that lead to maximum catalytic behavior at the nanointerfaces. This optimization is important for future works in which the conjugates will be used to decontaminate bacteria such as E. Coli and B. Cereus spores.


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