408 Biophysical Behavior of Pharmaceutical Proteins in Processing, Storage and Delivery Environments II

Wednesday, October 31, 2012: 8:30 AM
Pennsylvania West (Westin )
Processing, storage and delivery can subject pharmaceutical proteins to physical and chemical stresses, decreasing biological activity. In this session we will explore both the biophysical characterization of pharmaceutical proteins in process-, storage- and delivery-relevant environments and processing-, formulation- and protein engineering-based manipulation of biophysical behavior to preserve biological activity in these environments.

Biomedical Applications of Chemical Engineering
Bioengineering (15c)

Todd M. Przybycien
Email: toddp@andrew.cmu.edu

Robert D. Tilton
Email: tilton@andrew.cmu.edu

9:10 AM
(408b) Engineering and Characterizing Aggregation-Resistant Antibodies
Joseph M. Perchiacca, Shantanu V. Sule, Ali Reza A. Ladiwala, Jayapriya Jayaraman, Moumita Bhattacharya and Peter M. Tessier

9:30 AM
(408c) Characterization of Monoclonal Antibody Conformations and Self-Associations At High Concentrations Using Neutron Scattering Techniques
Yun Liu, Eric J. Yearley, Isidro Zarraga, Norman J. Wagner, Thomas M. Scherer, Steven J. Shire and Yatin R. Gokarn

9:50 AM

10:00 AM
(408d) Aggregation of Proteins Studied by Deep UV Resonance and Nonresonance Raman Spectroscopy
Sergey Arzhantsev, Connie Ruzicka, Vincent Vilker and John Kauffman

10:40 AM
(408f) Low-Viscosity Highly Concentrated Dispersions of Stable Protein Nanoclusters for Subcutaneous Injection
Aileen K. Dinin, Ameya U. Borwankar, Maria Andrea Miller, Tarik A. Khan, Brian Wilson, Kevin Kaczorowski, Jennifer A. Maynard, Thomas M. Truskett and Keith P. Johnston