408 Biophysical Behavior of Pharmaceutical Proteins in Processing, Storage and Delivery Environments II

Wednesday, October 31, 2012: 8:30 AM
Pennsylvania West (Westin )
Description:
Processing, storage and delivery can subject pharmaceutical proteins to physical and chemical stresses, decreasing biological activity. In this session we will explore both the biophysical characterization of pharmaceutical proteins in process-, storage- and delivery-relevant environments and processing-, formulation- and protein engineering-based manipulation of biophysical behavior to preserve biological activity in these environments.

Sponsor:
Biomedical Applications of Chemical Engineering
Co-Sponsor(s):
Bioengineering (15c)

Chair:
Todd M. Przybycien
Email: toddp@andrew.cmu.edu

Co-Chair:
Robert D. Tilton
Email: tilton@andrew.cmu.edu


8:30 AM
(408a) Stimulus-Responsive Controlled Release System by Covalent Immobilization of Proteins Into Mesoporous Silica Nanoparticles
Kai H. Griebenow

9:10 AM
(408b) Engineering and Characterizing Aggregation-Resistant Antibodies
Joseph M. Perchiacca, Shantanu V. Sule, Ali Reza A. Ladiwala, Jayapriya Jayaraman, Moumita Bhattacharya and Peter M. Tessier

9:30 AM
(408c) Characterization of Monoclonal Antibody Conformations and Self-Associations At High Concentrations Using Neutron Scattering Techniques
Yun Liu, Eric J. Yearley, Isidro Zarraga, Norman J. Wagner, Thomas M. Scherer, Steven J. Shire and Yatin R. Gokarn

9:50 AM
Break

10:00 AM
(408d) Aggregation of Proteins Studied by Deep UV Resonance and Nonresonance Raman Spectroscopy
Sergey Arzhantsev, Connie Ruzicka, Vincent Vilker and John Kauffman

10:20 AM
(408e) Reactivity of Polymersome Encapsulated Hemoglobin with Physiologically Important Gaseous Ligands: Oxygen, Carbon Monoxide, and Nitric Oxide
Shahid Rameez, Uddyalok Banerjee, Jorge Fontes, Alexander Roth and Andre Palmer

10:40 AM
(408f) Low-Viscosity Highly Concentrated Dispersions of Stable Protein Nanoclusters for Subcutaneous Injection
Aileen K. Dinin, Ameya U. Borwankar, Maria Andrea Miller, Tarik A. Khan, Brian Wilson, Kevin Kaczorowski, Jennifer A. Maynard, Thomas M. Truskett and Keith P. Johnston
See more of this Group/Topical: Topical 7: Biomedical Applications of Chemical Engineering
<< Previous Session | Next Session >>