187 Alternative Crystallization Technologies and Case Studies of Crystallization Processes

Tuesday, October 30, 2012: 8:30 AM
Crawford West (Westin )
Description:
As in-situ particle engineering becomes a focus of industrial crystallization, alternative technologies are being developed in order to predictably control particle properties. Increasing interest towards continuous crystallization is also contributing to the need for new crystallization technologies. Standard batch crystallizations are generally performed in a stirred tank and continuous crystallizations are being developed in stirred tanks or in tubular crystallizers. Alternative crystallization technologies can include non-conventional equipment/crystallizer configurations in order to perform batch/continuous crystallizations. Many current technologies under development focus on particle micronization and/or nano-crystallization which may include; micro-reactors, impinging jets, or crystallization from an emulsion. Submissions to this session can focus on (1) alternative crystallization equipment, processing technologies, or other unique approaches to carrying out a crystallization, or (2) novel approaches for carrying out crystallization or post-crystallization processing for desired product characteristics. The papers should use case studies and specific examples to illustrate the new methods.

Sponsor:
Crystallization and Evaporation
Co-Sponsor(s):
Solids Flow, Handling and Processing (03C), Pilot Plants (12b)

Chair:
Co-chairs:
Michael A. Lovette
Email: mlovette@lilly.com

Bruce D. Hook
Email: BDHook@dow.com

- indicates paper has an Extended Abstract file available on CD.

File available
9:06 AM
(187c) Design and Characterization of a Continuous Stirred Tank Crystallizer
Gary Morris, Guangyang Hou, Mark Barrett and Brian Glennon

9:24 AM

9:42 AM
(187e) Investigation of a Counter-Current Crystallization Process for Separation of Systems Forming Solid Solutions
Erik Temmel, Sebastian Wloch, Uwe Müller, Detlef Grawe, Robert Eilers, Heike Lorenz and Andreas Seidel-Morgenstern

10:00 AM
(187f) Designing a Fit-for-Purpose Agglomeration Method for Pharmaceutical Crystals
Chenchi Wang, Daniel Hsieh, Mario Hubert and Chiajen J. Lai

10:18 AM
(187g) Utilization of Population Balance Models to Develop a Continuous Crystallization Process; Determination of Crystallization Kinetics
Christopher L. Burcham, Michael A. Lovette, Christopher S. Polster, Sean K. Bermingham and Hassan Mumtaz

10:36 AM
(187h) Utilization of Population Balance Models to Develop a Continuous Crystallization Process; Process Design Using Optimization
Christopher L. Burcham, Michael A. Lovette, Christopher S. Polster, Sean K. Bermingham and Hassan Mumtaz
See more of this Group/Topical: Separations Division