170 Solid Form Selection: Cocrystals, Salts, Solvates, Polymorphs and Beyond

Monday, October 29, 2012: 3:15 PM
Crawford West (Westin )
Description:
Continuous improvement of the physicochemical properties of active pharmaceutical ingredients (APIs) such as solubility, bioavailability, dissolution rate, stability, hygroscopicity, crystallinity and taste, represents an emerging area of research and development. This session focuses on the selection of solid forms including cocrystals, salts, solvates and polymorphs in crystallization processes, as well as the screening, predicting, manipulating and controlling techniques for such product selection.

Sponsor:
Crystallization and Evaporation

Chair:
Ann M. Czyzewski
Email: ann.czyzewski@abbott.com

Co-Chair:
Fang Wang
Email: fang.wang@gilead.com


3:15 PM
(170a) Identification, Characterization and Development of a Betaine Co-Crystal for a Pharmaceutical Compound
Bing-Shiou Yang, Zhibin Li, Ka Yip, Soojin Kim, Daniel Fandrick, Jeff Song, Nathan Yee and Chris Senanayake

3:35 PM
(170b) Polymorph Screening Using Self-Assembled Monolayers and Scale-up of Metastable Forms
Jie Chen and Allan S. Myerson

3:55 PM
(170c) Transformation of an Amorphous API to Crystalline Hydrate and Co-Crystals
Fang Wang, Ernest Carra, Anna Chiu and Jesper Jernelius

4:15 PM
(170d) Solvent Compatible Microfluidic Platforms for Solid Form Screening of Pharmaceutical Parent Compounds
Sachit Goyal, Yuchuan Gong, Geoff G.Z. Zhang and Paul J.A. Kenis

4:35 PM
(170e) Computational Crystal Structure Prediction of Organic Molecules
Erik E. Santiso, Andrei V. Kazantsev, Manolis Vasileiadis, Claire S. Adjiman and Constantinos C. Pantelides

4:55 PM
(170f) Computational Study of Polymorph Selection in Glycine
Nathan Duff and Baron Peters

5:15 PM
(170g) Influence of Polymeric Additives On the Nucleation Kinetics, Growth, and Polymorph Selectivity of Calcium Salts
Mitali China, Priyanka Rajaram and Marina Tsianou
See more of this Group/Topical: Separations Division
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