402 Applications of Continuous Processing in Manufacture of Pharmaceuticals: Drug Product

Wednesday, October 31, 2012: 8:30 AM
Allegheny III (Westin )
Pharmaceutical manufacturing has been dominated by the batch processing concept, where each unit dosage form is produced in a batch and tracked accordingly. However, over the last decade continuous manufacturing of active pharmaceutical ingredients (APIs) and drug products has become increasingly important as there are many advantages, such as reduced capital and operational costs, as well as real-time quality control for increased process reliability and reproducibility. Thus, this session invites speakers to present their scientific efforts in the area of continuous processing for API and drug product manufacturing.

Particle Production and Characterization (03a)

William R. Ketterhagen
Email: william.ketterhagen@pfizer.com

Stelios Tsinontides
Email: stsinont@cephalon.com

8:30 AM
(402a) Continuous Pharmaceutical Hot-Melt Extrusion and Hot-Die Face Pelletizing
Daniel Treffer, Andreas Eitzlmayr, Clemens-Michael Smola, Gerold Koscher, Eva Roblegg and Johannes G. Khinast

8:51 AM
(402b) Predictive Modeling of Hot Melt Extruders
Andreas Eitzlmayr, Daniel Treffer, Gudrun Hoerl, Sarah Windhab, Gerold Koscher and Johannes G. Khinast

9:12 AM
(402c) Foam Granulation Extrusion: A Novel Method to Continuous Wet Granulation of Powder Drug Formulations
Michael R. Thompson, Sharleen Weatherley, Rohan Pukadyil and Paul Sheskey

9:33 AM
(402d) Powder Feeder Pairing with Downsteam Continuous Mixer
William E. Engisch Jr. and Fernando J. Muzzio

9:54 AM
(402e) Powder Lubrication in a Continuous Mixing Process
Daniel O. Blackwood, Bruce C. MacDonald, Joseph Kushner IV, Bruno C. Hancock and Yang A. Liu

10:15 AM
(402f) Effect of Paddle Shape On Flow of Powder Through Feed Frames On Rotary Tablet Presses
G. Singh, J. Givand, P. Rajniak, R. Chern, S.D. Reynolds and I.C. Sinka

10:36 AM
(402g) Supply Chain Analysis of Continuous Pharmaceutical Manufacturing
Arul Sundaramoorthy, James M.B. Evans and P.I. Barton