15 Bioseparations and Downstream Processing

Monday, October 29, 2012: 8:30 AM
Westmoreland East (Westin )
Description:
This session will focus on highlighting the latest advances in downstream processing relevant to purification/polishing operations including rapid process development, improved efficiency, cost reduction, integration of operations, handling of high titre streams and sustainability issues. Topics to be covered include, but are not limited to: Uni- and multi-modal chromatography, membrane-based separations and filtration, extraction, precipitation and crystallization.

Sponsor:
Bioengineering
Co-Sponsor(s):
Bio Separations (02G)

Chair:
Caryn L. Heldt
Email: heldt@mtu.edu

Co-Chair:
Peter Martin
Email: P.Martin@manchester.ac.uk


8:30 AM
(15a) Chemical Grafting of Chromatographic Resins for the Selective Adsorption of Pegylated Proteins
Aguilar Oscar and Hernández-Martínez Agustín

8:48 AM
(15b) Control of Intein-Mediated Recombinant Protein Purification in a Chinese Hamster Ovary (CHO) Cell Expression System
Tzu-Chiang Han and David W. Wood

9:06 AM
(15c) Excipients Removal by Capto S Chromatography and UF/DF Process Development for High-Concentration Drug Substance Production
Gregory Waszak, Larry Determan Jr. and Joseph Martin Jr.

9:24 AM
(15d) Designing in Process Robustness: Minimizing Proteolysis Through Analytical and Chromatographic Tools
Janelle Konietzko, Andrew Englehart, Thomas Svab, Adam Kristopeit, Marc Wenger, Michael E. Laska and Aaron R. Goerke

9:42 AM
(15e) Proteomics Based Multivariate Random Forest Method for Prediction of Protein Separation Behavior During Downstream Purification
Ryan K. Swanson, Ruo Xu, Dan Nettleton and Charles E. Glatz

10:00 AM
(15f) Virus Purification by Aqueous Two Phase Extraction System
K. Saagar Vijayaragavan and Caryn L. Heldt

10:18 AM
(15g) The Effect of Single-Use Retentate Recycle Bag Design On Diafiltration Efficiency
David M. Bohonak and Elizabeth Goodrich

10:36 AM
(15h) Flux Enhancement in Recycling Cellulase From Enzymatic Hydrolyzate of Acid Treated Wheat Straw by Electroultrafiltration
Guoqiang Chen and Yinhua Wan
See more of this Group/Topical: Food, Pharmaceutical & Bioengineering Division - See also TI: Comprehensive Quality by Design in Pharmaceutical Development and Manufacture
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