47 Protein Engineering I - Therapeutics

Monday, October 29, 2012: 8:30 AM
Fayette (Westin )
This session will focus on protein engineering for therapeutic applications with an emphasis on emerging topics and recent successes. Possible areas of interest include, but are not limited to, (1) advances in protein-based therapeutics, (2) proteins for cellular targeting and imaging, and (3) proteins involved in disease pathology.


Michael C. Jewett
Email: m-jewett@northwestern.edu

Jin Ryoun Kim
Email: jkim@poly.edu

8:30 AM
(47a) Design of Potent Antibody Inhibitors of Amyloid Fibrillization
Ali Reza A. Ladiwala, Moumita Bhattacharya, Joseph M. Perchiacca and Peter M. Tessier

9:06 AM
(47c) Computationally Driven Therapeutic Protein Deimmunization
Regina S. Salvat, Andrew S. Parker, Daniel C. Osipovitch, Chris Bailey-Kellogg and Karl E. Griswold

9:24 AM
(47d) Improved Protein Switches for Cancer-Activated Enzyme Prodrug Therapy
R. Clay Wright, Arjun Khakhar, Chapman M. Wright, James R. Eshleman and Marc Ostermeier

9:42 AM
(47e) Engineered Hepatocyte Growth Factor Mutants: New Tools for Tissue Regeneration and Vascularization
Cassie Liu, Douglas S. Jones, Ping-Chuan Tsai and Jennifer R. Cochran

10:00 AM
(47f) Enzyme Prodrug Therapy Targeted to Breast Tumor Vasculature Using a Recombinant Fusion Protein
John Krais, Vassilios I. Sikavitsas, Carla Kurkjian and Roger G. Harrison

10:36 AM
(47h) Cell-Based Biosensors for Dynamically Imaging Immune Function in Vivo
Nichole Daringer, Rachel M. Dudek and Joshua N. Leonard