262 Biophysical Behavior of Pharmaceutical Proteins in Processing, Storage and Delivery Environments I

Tuesday, October 30, 2012: 12:30 PM
Pennsylvania West (Westin )
Description:
Processing, storage and delivery can subject pharmaceutical proteins to physical and chemical stresses, decreasing biological activity. In this session we will explore both the biophysical characterization of pharmaceutical proteins in process-, storage- and delivery-relevant environments and processing-, formulation- and protein engineering-based manipulation of biophysical behavior to preserve biological activity in these environments.

Sponsor:
Biomedical Applications of Chemical Engineering

Chair:
Todd M. Przybycien
Email: todd@andrew.cmu.edu

Co-Chair:
Robert D. Tilton
Email: tilton@andrew.cmu.edu

- indicates paper has an Extended Abstract file available on CD.


12:30 PM
(262a) Protein Behavior At Pharmaceutically-Relevant Microparticle Interfaces
Theodore W. Randolph

1:10 PM
(262b) Single Molecule Protein Dynamics and Aggregation At the Oil-Water Interface
Robert Walder and Daniel K. Schwartz

1:30 PM
(262c) Does Poly(ethylene glycol) Conjugation Protect Proteins From Conformational Change During Emulsion-Based Microsphere Encapsulation?
Adam L. Canady, Todd M. Przybycien and Robert D. Tilton

1:50 PM
Break

2:00 PM
(262d) Structure and Stability of Pol(L-lysine)/Hyaluronan Thin Films As Nanoreservoirs for the Bone Morphogenetic Protein-2
Flora Gilde, Ofelia Maniti, Raphael Guillot, Jorge Almodovar and Catherine Picart

2:20 PM
(262e) Formulation of Bovine Serum Albumin Encapsulated Cal-Alginate Microspheres by Electrodispersion for a Simulated Release in a Gastric Fluid
Yinyan Zhao, Fuyue Li and Michael T. Harris
File available
2:40 PM
(262f) Design of a Vessel to Facilitate Rapid Thawing of a Labile Protein
Robert Large and Ajoy K. Velayudhan
See more of this Group/Topical: Topical 7: Biomedical Applications of Chemical Engineering
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