291947 Interfacial Interactions of Zero Dimentional Carbon Nanotubes and Their Applications As Thin Films: A Potential Platform for Cell Growth

Monday, October 29, 2012
Hall B (Convention Center )
Meghana Patil1, Riccardo Gottardi2,3,4,5, Sachin Velankar2 and Steven R. Little1,5,6,7, (1)Bioengineering, University of Pittsburgh, Pittsburgh, PA, (2)Department of Chemical and Petroleum Engineering, University of Pittsburgh, Pittsburgh, PA, (3)Department of Orthopaedic Surgery, University of Pittsburgh, Pittsburgh, PA, (4)Fondazione RiMED, Palermo, Italy, (5)McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA, (6)Chemical and Petroleum Engineering, University of Pittsburgh, Pittsburgh, PA, (7)Immunology, University of Pittsburgh, Pittsburgh, PA

Amongst their many unique properties, single-walled carbon nanotubes (SWNT) have specific limitations, including non-uniformity in length, frequent defect sites, and low dispersibility in solution. To overcome these limitations, researchers at the Little Lab developed “zero dimensional” single-walled carbon nanotubes (0dSWNT), less than 10 nm in length and much more dispersible in solution.

The aim of this research was to create a more usable form of 0dSWNT by creating thin films using the concept of interfacial film climbing in an oil/water emulsion. Using a heptane/water emulsion, the film-climbing property of the SWNT and 0dSWNT was video-recorded for verification. A pendant drop experiment with nanotubes dispersed in water was used to determine whether a reduction of interfacial tension contributes to film-climbing. Next, thin films of SWNT and 0dSWNT were made on glass slides and coverslips by this technique. As a potential application, SWNT and 0dSWNT thin films on coverslips were used as a substrate for hMSC growth and potential differentiation towards a neuronal lineage. After three days of culture, cell growth was dense, and the samples were fixed and stained. Ultimately the thin, uniform films created by the film-climbing technique proved to be an effective substrate for the cells.


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