291296 Electropolymerizable Membranes to Enhance Selectivity of Implantable Glucose Sensors

Monday, October 29, 2012
Hall B (Convention Center )
Kimberly Dout, University of Connecticut, Storrs, CT

Continuous glucose monitoring is expected to decrease diabetes complications by providing a means of stringent glucose control. Currently available glucose sensors for continuous glucose monitoring are plagued by a variety of issues such erroneous glucose levels due to endogenous interferences. The focus of this research involves blocking electroactive interferences that alter the glucose reading. Herein, it is shown that the utilization of an electropolymerized polyphenol (PPh) membrane alleviates the problem of interferences by blocking them through size exclusion.  Studies have also been carried out to elucidate the relationship between the swelling of PPh and its ability to block the interferences. For this, sensors have been incubated and tested both in normal PBS buffer as well as complex procine serum. The results showed that sensors soaked in serum decreased in sensitivity due to protein blockage while sensors soaked in a phosphate buffer solution increased in sensitivity of glucose and interferences, but not significantly. The results of this experiment could be used to calibrate glucose sensors for long periods of time in the human body.

Extended Abstract: File Not Uploaded
See more of this Session: Student Poster Session: Materials Engineering and Sciences
See more of this Group/Topical: Student Poster Sessions