Basic Structural Analysis of the Wall Motion of Chick Embryonic Outflow Tracts

•Analyzing the development of the heart under changed hemodynamic conditions will help us understand how congenital heart defects develop.

•Changes in the wall motion of the outflow tract can lead to the development of structural heart defects.

•This lab studies the outflow tract because it is a sensitive area of the heart that is susceptible to structural change.

•The outflow tract is located between the ventricle and the atrium as shown in Figure 3.

•Blood flow is changed by physically banding the outflow tract with a small suture.

•Embryos are imaged before banding(BB), after banding(AB) and 2 hours after banding(2HAB) by the optical coherence tomography imaging system (Figure 2)

•Expansion and contraction of the outflow tract is measured in micrometers. Expansion is defined as the maximum distance between the upper and lower wall and contraction is the minimum distance between the upper and lower wall of the outflow tract. 

The objective of this lab is to determine the structural difference (if any) between a normal embryo and a banded embryo.

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