288658 Assemblies of Plasmonic Nanoparticles and Their Biomedical Applications
Assemblies of Plasmonic Nanoparticles and Their Biomedical Applications
Prof. Nicholas Kotov
Department of Chemical Engineering, University of Michigan, Ann Arbor, MI, 48198, USA
Plasmons of gold nanoparticles (NPs) represent one of the best examples of collective properties of nanoscale systems. Engineering of nanoscale assemblies of Au NPs opens great prospects for biomedical applications. The presentation will include the state-of-the-art account of preparation and properties of both extended and discrete assemblies of plasmonic NPs. The first type of assemblies includes supercrystals of gold spheres and nanorods (NRs) and layered composites from the same building blocks made by the layer-by-layer assembly. The second type of assemblies covers the small superstructures of 3-30 NPs or NRs. Methods to control the structure of both assemblies and how these properties affect the application-defining optical, electrical, and mechanical properties will be discussed.
The application space to be covered in this presentation includes cancer/inflammation detection using photoacoustic imaging, drug delivery, photodynamic cancer treatment, continuous monitoring of cellular metabolism, and neuroprosthetic dev ices. The latter represent particularly unexplored area of research for gold nanostructures and will greatly benefit from the unique combination of optical, mechanical, and biological properties of plasmonic NP assemblies. New directions of research in this area will also be mapped out and include (1) chiral plasmonic nanoassemblies; (2) artificial viruses from inorganic NPs; (3) NPs from non-metal plasmonic materials; and (4) biodegradable inorganic NPs and assemblies.
Special attention will be made on new methods of evaluation of toxicology of nanoparticles involving three-dimension cell cultures in spheroids of liver cells which displayed unexpected transport characteristics of NPs in the tissue.
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