Characterization of Adhesion Between Chemical Robots and Biological Cells

 

Characterization of Adhesion between Chemical Robots and Biological Cells

 

Viola Tokarova,*Frantisek Stepanek

Institute of Chemical Technology Prague, Department of Chemical Engineering, Technická 5, Prague 6, 166 28, Czech Republic, *e-mail: frantisek.stepanek@vscht.cz

Composite microparticles or microcapsules for targeted delivery of active substances such as antibacterial agents or pharmaceutical compounds are of both practical and fundamental interest. The purpose of such delivery vehicles is to store the active compound at a high concentration, transport it through an environment in which the presence of the active compound is not required (or not desirable), and eventually anchor to the target site and release the encapsulated payload either spontaneously or upon an external stimulus. For the design a targeted delivery system, not only the release kinetics of the encapsulated compound from the microcapsule but also the specific interactions of the microcapsules with the target point of controlled release –  their adhesion properties – are crucial.

This work describes synthesis steps of such composite microcapsule and their surface modification. The specific antigen-antibody adhesion properties and characterization inside microfluidic cell will be presented.