277246 Scale-up Approaches to Preserve Particle Properties of Api's in Agitated Filter Driers

Monday, October 29, 2012: 4:05 PM
Shadyside (Omni )
David am Ende and Mark T. Maloney, Chemical R&D, Pfizer, Inc, Groton, CT

Agitated Filter Driers (AFD’s) are commonly used in the pharmaceutical manufacturing for performing both filtration and drying operations.  Successful scale-up from lab to manufacturing AFD equipment requires that the physical properties be met. These properties include product quality such as purity and particle size.  Depending on the API-solvent system and other operational parameters, undesired attrition or agglomeration may occur impacting the desired particle properties.  In such cases mitigation strategies are needed for scale-up that minimize agitation during drying while maintaining acceptable drying rates and ultimately preserving particle properties.  The focus of this presentation will be to describe our modeling and scale-up approaches into agitated filter driers with an emphasis on the challenging API’s with propensity for agglomeration or attrition during drying.

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See more of this Session: Process Scale-up Techniques
See more of this Group/Topical: Process Development Division