275359 Macromolecular Drug Delivery for Cancer Therapy
The use of macromolecular therapeutic agents e.g., monoclonal antibodies and nucleic acids has come to the forefront in recent years for the treatment of cancer. However, several challenges, including cell target specificity, intracellular delivery, low therapeutic payload, biologically active drug concentration and toxicity, still prevail for eliciting effective responses from cancer cells to therapy. My post-doctoral research with Professor Samir Mitragotri at University of California, Santa Barbara focuses on synthesis of advanced engineered nanoparticles with controlled size, shape and surface chemistry for targeted delivery of therapeutic drug macromolecules. My Ph.D. thesis research under the guidance of Professor Kaushal Rege at Arizona State University, Tempe focused on combination treatment strategies for non-viral gene delivery to induce apoptotic cancer cell death. In this poster session, I will highlight examples from my graduate and postdoctoral research which demonstrate the ability of synthetic nano-biomaterials in delivery of drugs, antibodies, and nucleic acids. I will present my vision for my independent research program at the interface of nanotechnology and cancer therapy that encompasses: 1) development of new carrier systems with specific cellular and sub-cellular target effects for cancer therapy, and 2) detailed mechanistic investigations of sub-cellular interactions between synthetic materials and sub-cellular organelles.
EDUCATION:
B.Sc., Chemical Engineering, 2003, Bangladesh University of Engineering & Technology (BUET), Dhaka, Bangladesh
M.Sc. in Chemical Engineering, 2007, Montana State University (MSU), MT, USA
Ph.D. in Chemical Engineering, 2011, Arizona State University (ASU), AZ, USA
EXPERIENCE:
Post-doctoral Researcher, Chemical Engineering, University of California, Santa Barbara, Santa Barbara, CA; 07/2011-present
Graduate Research Assistant/Associate
Chemical Engineering, Arizona State University, AZ; 08/2007- 05/2011
Chemical, Biological Engineering, Montana State University, MT; 08/2005- 08/2007
Chemical Engineering, Washington State University, WA; 08/2004- 08/2005
Teaching (Lecturer), Chemical Engineering, Bangladesh University of Engineering & Technology (BUET), Dhaka, Bangladesh; 02/2003- 07/2004
SELECTED PUBLICATIONS:
Barua, S.; Ramos, J.; Potta, T.; Taylor, D.; Huang, H.C.; Montanez, G.; Rege, K., Review on Discovery of Cationic Polymers for Non-viral Gene Delivery. Combinatorial Chemistry & High Throughput Screening, 2011, 14(10), 908-24
Barua, S.; Rege, K., The influence of Mediators of Intracellular Trafficking on Transgene Expression Efficacy of Polymer-plasmid DNA Complexes. Biomaterials, 2010, 31 (22), 5894-5902
Barua, S.; Joshi, A.; Banerjee, A.; Matthews, D.; Sharfstein, S. T.; Cramer, S. M.; Kane, R. S.; Rege, K., Parallel Synthesis and Screening of Polymers for Nonviral Gene Delivery. Molecular Pharmaceutics, 2009, 6 (1), 86-97
Barua, S.; Rege, K., Cancer-Cell-Phenotype-Dependent Differential Intracellular Trafficking of Unconjugated Quantum Dots. Small, 2009, 5 (3), 370-376
MANUSCRIPTS IN PREPARATION
Barua, S.; Voelkel-Johnson, C.; Von Hoff, D.D.; Han, H.; Rege, K., Inhibition of Aurora Kinases Enhances Transgene Expression and Cancer Cell Apoptosis following delivery of Polymer-Plasmid DNA Complexes. In preparation, 2012
Barua, S.; Yoo, J.W.; Mitragotri, S., Endocytosis of Nano- and Microparticles in Breast Cancer Cells. In preparation, 2012
AWARDS/ HONORS:
3rdplace, poster competition, National Nanotechnology Infrastructure Network Symposium, Arizona State University, 2011
Outstanding Research Assistant Award, Chemical Engineering, Arizona State University, 2009
Travel Grant Awards, Arizona State University, 2009 and 2010
Participant, 57th Lindau meeting with 18 honorable Nobel Laureates in Lindau, Germany, 2007
2ndplace, poster competition of the Intermountain Systems Biology Symposium, 2007
INRA (Inland Northwest Research Alliance) fellowship, Montana State University, 2005-2007
2ndplace poster competition, William R. Wiley Exposition at Washington State University, 2005
Dean List Awards, Bangladesh University of Engineering & Technology (BUET), 1999-2002
Scholarship, Bangladesh Scholarship Council and the Nippon Foundation, Japan, 1998 and 2000
See more of this Group/Topical: Education Division