272093 Determination of Crystal Growth Rates for Solids Growing From Multiple-Conformers Solutions and Evidence of Growth Inhibition by the Wrong Conformer

Wednesday, October 31, 2012: 1:00 PM
Crawford West (Westin )
Lotfi Derdour, Drug Product Science and Technology, Bristol-Myers Squibb co., New Brunswick, NJ and Chandrasekar Sivakumar, Chemical Engineering, Carnegie Mellon University, Pittsburg, PA

The validity of a model derived for crystal growth rate for solids crystallized from solutions containing multiple conformers is evaluated. A simple and straightforward method for determining crystal growth rates using FBRM and FTIR/ATR is utilized to maximize growth rate data collected from a single experiment. Crystal growth rate data obtained experimentally were in good agreement with model predictions. In particular, the data indicated that when the approach of the right conformer (Derdour et al[1]) applies, crystal growth rate is inversely proportional to crystal size. Further, the results indicate that growth rates determined from supersaturation measurements can be over-estimated because of surface nucleation and/or agglomeration that can result from supersaturation spikes during anti-solvent addition. Lastly, crystal growth data obtained at different temperatures indicated that the slow growth rate observed at low temperatures may be caused in part by surface poisoning by the wrong conformer.

1       Derdour et al., Crystallization from solutions containing multiple conformers: A new modeling approach for solubility and supersaturation, Chem Eng Sci., 66(1), pp. 88-102, 2011.

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See more of this Session: Nucleation and Growth II
See more of this Group/Topical: Separations Division