263172 CFD Simulation of Pharmaceutical Particle Drying in Bubbling Fluidized Bed Dryers At Different Scales

Monday, October 29, 2012: 4:12 PM
Conference C (Omni )
Hamid Arastoopour, IIT, Chicago, IL and Jungkee Jang, Chemical and Biological Engineering, Illinois Institute of Technology, Chicago, IL

CFD Simulation of Pharmaceutical Particle Drying in Bubbling Fluidized Bed Dryers at Different Scales

Jungkee Jang and Hamid Arastoopour

Department of Chemical and Biological Engineering, Illinois Institute of Technology, USA

Drying is one of the major unit operations in the manufacturing of solid pharmaceuticals. The optimum design of this process will significantly enhance the rate and reliability of the production and, in turn, decrease the cost of the pharmaceutical products. In this study, the gas-solid mixing and drying processes of pharmaceutical particles in bubbling fluidized bed dryers at different scales were simulated using a two-fluid granular model. Our mathematical model is composed of the continuity, momentum, energy, and species transfer equations for water vapor to simulate the flow pattern and heat and mass transfer for the pharmaceutical bubbling fluidized bed dryer process. User defined scalar (UDS) transport equations were added to extend the FLUENT code capability to account for moisture transport and to simulate the drying rate and extent of the solid particles.

The simulations were performed at different particle diameters, bed heights, inlet gas velocities, and inlet gas temperature distributions, respectively. Our simulation results were validated and refined by comparing with Duquesne University laboratory-scale experimental data on solid particles moisture content and outlet gas temperature. Then, our CFD model was used to predict larger scale (kilo- and 10-kilo scale units) Abbott Laboratory data for the drying process of the same material. Our simulation results compared well with the experimental data for the drying process for all three different scales.


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