253602 Combinatorial Chemistry and High Throughput for Anti-Fouling Membranes

Tuesday, October 30, 2012: 12:30 PM
Cambria West (Westin )
Minghao Gu1, Arturo Vegas2, Daniel G. Anderson2, Robert Langer2 and Georges Belfort3, (1)Howard P. Isermann Deptt of Chemical & Biological Engineering and The Center for Biotechnology & Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, NY, (2)Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, (3)Department of Chemical and Biological Engineering, Rensselaer Polytechnic Institute, Troy, NY

Modifying filtration membranes using graft polymerization is an attractive alternate to developing new polymers with anti-fouling characteristics.  To expand, refine and optimize the discovery and separation characteristics of new surfaces using the 96-membrane well format with high throughput–atmospheric pressure plasma (HTP-APP) method and to elucidate the behavior of protein-resistant chemistries, we use combinatorial chemistry to prepare an expanded library of vinyl monomers, graft these newly synthesized monomers, test their efficacy for improving filtration performance, and select winners; and fine-tune the grafting and filtration conditions of selected winners.  We react acid vinyl monomers or methacryloyl chloride with a series of amine vinyl compounds to obtain new vinyl amide monomers for graft polymerization.  For selected compounds, we have purified, fractionated and confirmed their structure with mass spectroscopy.  A number of amide monomer-modified PES membranes were identified with the lower fouling and higher permeation than the unmodified or control membrane.  Their low protein-resistant properties are comparable with previously identified surfaces.

Extended Abstract: File Not Uploaded