Applications of Continuous Processing In Manufacture of Drug Product

Wednesday, October 19, 2011: 12:30 PM
Conrad A (Hilton Minneapolis)

Description:
Pharmaceutical manufacturing has been dominated by the batch processing concept, where each unit dosage form is produced in a batch and tracked accordingly. However, over the last decade continuous manufacturing of active pharmaceutical ingredients (APIs) and drug products has become increasingly important as there are many advantages, such as reduced capital and operational costs, as well as real-time quality control for increased process reliability and reproducibility. Thus, this session invites speakers to present their scientific efforts in the area of continuous processing for API and drug product manufacturing.


Sponsor:
Pharmaceuticals


Chair:
William R. Ketterhagen
Email: william.ketterhagen@pfizer.com

Co-Chair:
Adam S. Butterbaugh
Email: butterbaughas@lilly.com




12:55 PM
(506b) A Plant-Wide Dynamic Model of a Continuous Pharmaceutical Process
Brahim Benyahia, Richard Lakerveld and Paul I. Barton


1:20 PM
(506c) NIR Spectroscopy with Multivariate Statistical Process Control for Selected Pharmaceutical Processes
Nicolas Heigl, Patrik Wahl, Otto Scheibelhofer, Daniel Koller, Merten Schlingmann, Franz Reiter, Gerhard Straka and Johannes G. Khinast


1:45 PM
(506d) Optimizing Continuous Powder Mixing Processes Using Periodic Section Modeling
Yijie Gao, Fernando. J Muzzio and Marianthi G. Ierapetritou


2:10 PM
(506e) A Powder Mixing Model for a Small-Scale Continuous Mixing/Direct Compression Manufacturing Process
Daniel O. Blackwood, Bruno C. Hancock, Mark Polizzi, Bruce C. MacDonald, Hugh J. Clarke, Howard W. Ward II and Yang A. Liu


2:35 PM
(506f) Model-Based Control of An Integrated Continuous Pharmaceutical Manufacturing Process
Rohit Ramachandran, Anwesha Chaudhury and Marianthi G. Ierapetritou
See more of this Group/Topical: Food, Pharmaceutical & Bioengineering Division