Crystallization Process Development II - Case Studies

Monday, October 17, 2011: 3:15 PM
Marquette V (Hilton Minneapolis)

Description:
Crystallization is an important unit operation in the chemical industry, especially in the isolation and purification of pharmaceuticals and other fine chemicals. However, developing a crystallization process is a challenging problem in itself. The mixture to be separated often involves multiple components, and it is crucial that the solids are consistently obtained in the right polymorphic forms, compounds, adducts, or solvates. The particles need to be in the right size distribution in order to avoid problems such as difficult filtration or high residual impurity content. This session focuses on real-life case studies or examples on how crystallization processes are developed.


Sponsor:
Process Research and Innovation
Co-Sponsor(s):
Crystallization and Evaporation (02B)


Chair:
Christianto Wibowo
Email: cwibowo@cwbtech.com

Co-Chair:
Levente Simon
Email: levente.simon@basf.com



3:15 PM


3:40 PM
(149b) Crystallization-Based Integrated Process for the Resolution of a Pharmaceutically Relevant Intermediate
Jan von Langermann, Heike Lorenz, Malte Kaspereit, Martin Hedberg, Matthew J. Jones, Björn Herschend, Kerstin Larson, Mozzafar Shakeri, Jan-Erling Bäckvall, Achim Kienle and Andreas Seidel-Morgenstern



4:30 PM
(149d) Process Enhancements for a pH Sensitive Crystallization
John G. Gaertner, James Marek, Samrat Mukherjee, Shailendra Bordawekar and Mina Dimitri


4:55 PM
(149e) API-Crystal Preparation In A Continuously Seeded Tubular Crystallizer
Rafael J. P. Eder, Julia Grill, Elisabeth Schmitt, Simone Schrank, Eva Roblegg, Maximilian Besenhard, Stefan Radl, Heidrun Gruber-Woelfler and Johannes G. Khinast
See more of this Group/Topical: Process Development Division