Solid Form Selection: Cocrystals, Salts, Solvates, Polymorphs and Beyond

Tuesday, October 18, 2011: 3:15 PM
202 B (Minneapolis Convention Center)

Description:
Continuous improvement of the physicochemical properties of active pharmaceutical ingredients (APIs) such as solubility, bioavailability, dissolution rate, stability, hygroscopicity, crystallinity and taste, represents an emerging area of research and development. This session focuses on the selection of solid forms including cocrystals, salts, solvates and polymorphs in crystallization processes, as well as the screening, predicting, manipulating and controlling techniques for such product selection.


Sponsor:
Crystallization and Evaporation


Chair:
Fang Wang
Email: fang.wang@gilead.com

Co-Chair:
Alfred Lee
Email: alfred.lee@merck.com



3:15 PM
(410a) Separation of Impurities From Active Pharmaceutical Ingredients (APIs) by Selective Co-Crystal Formation
Kay (Huai-Ying) Hsi, Keith Chadwick, Amanda Fried, Allison Simi and Allan Myerson


3:40 PM
(410b) Applications of Solid Form Screen for the Purification of Pharmaceutical Compounds
Bing-Shiou Yang, Zhibin Li, Ka Yip, Soojin Kim, Dhileep Krishnamurthy, Nathan Yee and Chris Senanayake



4:30 PM
(410d) API Form Selection and Scale-up for a Complex Solid Form System: A Case Study of a Development Compound
Fang Wang, Ernest Carra, Benjamin Graetz, Eric Dowdy, Joanna Koziara and Yoo Joong Kim



5:20 PM
(410f) Polymorph and Crystal Habit Screening On a Microfluidic Platform
Michael R. Thorson, Sachit Goyal, Geoff G.Z. Zhang, Yuchuan Gong, Charles F. Zukoski and Paul J.A. Kenis
See more of this Group/Topical: Separations Division