Applications of Continuous Processing In Manufacture of Drug Substance

Wednesday, October 19, 2011: 8:30 AM
Conrad A (Hilton Minneapolis)

Pharmaceutical manufacturing has been dominated by the batch processing concept, where each unit dosage form is produced in a batch and tracked accordingly. However, over the last decade continuous manufacturing of active pharmaceutical ingredients (APIs) and drug products has become increasingly important as there are many advantages, such as reduced capital and operational costs, as well as real-time quality control for increased process reliability and reproducibility. Thus, this session invites speakers to present their scientific efforts in the area of continuous processing for API and drug product manufacturing.

Particle Production and Characterization (03a), Solids Flow, Handling and Processing (03C)

Heidrun Woelfler

Adam S. Butterbaugh

8:30 AM
(431a) Development of a Continuous Filter-Drier for Lab to Kilo-Lab Scale
David J. am Ende, David Pfisterer, Kevin Girard, Daniel Blackwood and Ed Plocharczyk

8:55 AM
(431b) Development of a Continuous Process for Tasisulam Sodium
Jennifer M. Groh, Timothy D. White, K. Derek Berglund and Martin D. Johnson

9:20 AM
(431c) API Attribute Control by Continuous Fast Crystallization/Precipitation
Dimitrios Zarkadas, Christopher Pridgen, Mourad Hamedi, Plamen Grigorov and Michael Whittington

9:45 AM
(431d) Efficient and Cost Effective Dehydration of Pharmaceutical Streams by Pervaporation
Dimitrios Zarkadas, Ronnie Feng, Michael Wu, Plamen Grigorov, Azzeddine Lekhal and Kevin Molter

10:10 AM
(431e) Failure Mode Analysis of Continuous Process with Process Models
Sze Wing (Candice) Wong, Prashant B. Kokitkar, K. Derek Berglund and Martin Johnson

10:35 AM
(431f) Novel Concepts for Continuous Purification of APIs Using Electro- Chromatography
Marie-G. Braunbruck, Heidrun Gruber-Woelfler, Peter Feenstra, Rene Laskowski, Hans-Joerg Bart and Johannes G. Khinast
See more of this Group/Topical: Food, Pharmaceutical & Bioengineering Division