Combinatorial Chemistries for Reducing Protein Adhesion with Plasma Grafting

Monday, October 17, 2011: 10:35 AM
M100 G (Minneapolis Convention Center)
Minghao Gu1, Arturo Vegas2, James Kilduff3, Daniel G. Anderson4, Robert Langer2 and Georges Belfort5, (1)Howard P. Isermann Deptt of Chemical & Biological Engineering and The Center for Biotechnology & Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, NY, (2)Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, (3)Civil and Environmental Engineering, Rensselaer Polytechnic Institute, Troy, NY, (4)Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, (5)Department of Chemical and Biological Engineering, Rensselaer Polytechnic Institute, Troy, NY

We describe here for the first time a new combinatorial approach for synthesizing a wide range of surface chemistries with the aim of searching for reduced protein adhesion.  In order to speed up the search, screening and selection procedure, we have utilized our novel high throughput platform (HTP) with atmospheric pressure plasma-induced graft polymerization (APPGP) to modify synthetic commercial membranes (poly(ether sulfone) PES).  Monomers are first added to the porous polymeric film and then grafted polymerization was performed.  Previously discovered monomers (poly(ethylene glycol) (PEG) and zwitterionic (Zwit) that exhibit protein-resistance were selected and so were new ones discovered.  Many of these newly discovered monomers appear to have potential for reducing protein adhesion.

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See more of this Session: Plasma Science and Technology
See more of this Group/Topical: Materials Engineering and Sciences Division