Multiphysics Modeling of Ambient Gas Plasma-Based Wound Healing Process

Wound healing is one of the promising applications of atmospheric pressure gas plasmas in medicine. A recent clinical study shows a significant reduction of bacterial load in treated wounds without side-effects. Plasma-generated reactive oxygen/nitrogen species (ROS/RNS) are thought to be key factors. But the fundamental mechanisms are only poorly understood. We have been developing a multiphysics model of plasma-based wound healing process. Our model consists of three parts: plasma generation region, ROS/RNS transportation in the afterglow, and gas plasma-stimulated wound healing. In the presentation, we will especially focus on the role of nitric oxide (NO) during the healing process.