Analysis of Channel Morphology for Electrophoresis of Biomolecules: Effect of Axial and Orthogonal Fields

Research involving polymer gels with embedded nanoparticles of varying properties is quite attractive because of the multitude of potential applications, including separation of biomacromolecules for clinical diagnostics, tissue scaffold growth etc. Moreover, analysis of the effects of the pore length and diameters on the transport of biomolecules is an important aspect to be studied either analytically or computationally as shown by previous efforts [1]. In this research, we propose to computationally analyze different pore models (associated with gel materials) and study the effect of geometry on the transport properties. Results will illustrate, for example, the role of pore-scale in conjunction with the effect of secondary electrical fields.

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1. Trinh, S., B.R. Locke and P.E. Arce, Separation and Purification Technology, 15, 255 (1999).