Biodegradable Graft Polymer-Drug Conjugate

Wednesday, October 19, 2011
Exhibit Hall B (Minneapolis Convention Center)
Yun Yu1, Jiong Zou1, Lu Yu1, Wei Ji2, Yukun Li1, Wing-Cheung Law2 and Chong Cheng1, (1)Department of Chemical and Biological Engineering, SUNY-Buffalo, Buffalo, NY, (2)Department of Chemistry, SUNY-Buffalo, Buffalo, NY

Functional polylactide-g-paclitaxel-poly(ethylene glycol), a novel graft polymer-drug conjugate (GPDC) with paclitaxel (PTXL) as the divalent agent to bridge between the degradable polylactide (PLA)-based backbone and hydrophilic poly(ethylene glycol) (PEG) side chains, were prepared by the copper-catalyzed azide-alkyne cycloaddition reaction of acetylene-functionalized polylactide (PLA) with  azide-functionalized PTXL-PEG conjugate.  The acetylene-functionalized PLA was prepared by ring-opening copolymerization (ROCP) of acetylene-functionalized LA monomer with L-lactide (LA).  The azide-functionalized PTXL-PEG conjugate was prepared by multi-step organic synthesis.  The well-controlled chemical structures of the GPDC and its precursors were verified by 1H NMR and GPC characterizations.  DLS analysis indicated that GPDC molecules assembled in water to form nanoparticles with sizes of 8-40 nm.  GPC analysis of buffer solutions (pH = 5.5 and 7.4) of the GPDC indicated the occurrence of multiple hydrolysis reactions under the experimental conditions, which resulted in the release of PTXL moieties and the cleavage of PLA-based backbone.

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See more of this Session: Mesd Poster Session
See more of this Group/Topical: Materials Engineering and Sciences Division