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Effect of Composition and Temperature On the Structural Evolution and Dissolution Behavior of Drug/Polymer Systems

Wednesday, October 19, 2011
Exhibit Hall B (Minneapolis Convention Center)
Qing Zhu1, Michael T. Harris1, Lynne Taylor2 and Hsin-Yun Hsu1, (1)Chemical Engineering, Purdue University, West Lafayette, IN, (2)Industrial and Physical Pharmacy, Purdue University, West Lafayette, IN

In this study, it is found that both the composition and crystallization temperature played important roles in determining the size and location of the drug domains in the polymer matrix and hence affect the dissolution behavior. By optimizing the preparation parameters, the formulation with desired performance can be designed.

Extended Abstract: File Not Uploaded
See more of this Session: Poster Session: Pharmaceutical Engineering
See more of this Group/Topical: Food, Pharmaceutical & Bioengineering Division