Drug Delivery Nanoparticles Modified by Zwitterionic Polymers

Wednesday, October 19, 2011
Exhibit Hall B (Minneapolis Convention Center)
Lei Zhang1, Zhiqiang Cao2 and Shaoyi Jiang1, (1)Chemical Engineering, University of Washington, Seattle, WA, (2)Department of Chemical Engineering, University of Washington, Seattle, WA

Zwitterionic polymers such as poly(carboxybetaine) (PCB) have shown excellent stealth and functioanlization properties and are potential alternatives to poly(ethylene glycol) (PEG) for a broad range of applications due to the instability of PEG. However, it is very difficult to combine PCB to any hydrophobic domains due to its super-hydrophilic property. This work introduces a generic method to covalently attach super-hydrophilic PCB to hydrophobic moieties by adopting the hydrolysable hydrophobic precursor of zwitterionic PCB. Base on this method, poly(lactic-co-glycolic acid) (PLGA)-PCB block copolymers were synthesized. We further demonstrate that drug delivery nanoparticles (NPs) assembled from such “sharp contrast” macromolecules exhibit unusual properties that are not found in any of current NP systems. Other types of NPs modified by PCB will also be discussed.

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See more of this Session: Mesd Poster Session
See more of this Group/Topical: Materials Engineering and Sciences Division