A 'fully' Disposable Primary Recovery Step for Harvesting Mammalian Cell Culture Systems: Focus of Depth Filtration Technologies

The advent of highly productive cell-culture processes for the production of recombinant proteins has driven smaller batch processing that provides opportunity for transforming conventional bioprocess trains into single-use operations.  We will be discussing the implementation of a disposable primary recovery step using Depth filtration technologies for harvesting recombinant proteins from high cell density cell cultures containing mammalian cells.  We will provide a technical overview of conventional Depth filtration performance capabilities and novel processing techniques including the pros and cons for implementing these clarification technologies