Synthesis of 7-Methoxy -4'-Substituted Flavones As Potential Pharmaceutically Active Compounds

A series of 7-methoxy-4'-substituted flavones were synthesized by the Baker-Venkataraman rearrangement approach, starting from 2-hydroxyl-4-methoxy acetophenone and 4-substituted benzoyl chlorides. High selectivity, short reaction times and good yields were reached. Several new flavones involving amino group were also synthesized with 7-methoxy-4'-nitroflavone as raw material. 7-methoxy-4'- aminoflavones were found to possess significant antioxidation, antitumor and anti-inflammatory effects, as well as the 7-methoxy-4'-nitroflavone.